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| Registros recuperados: 191 | |
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| Barreto,Raphael Gusmão; Brites,Carlos. |
| Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hypersensitivity; Antiretroviral; HIV; Abacavir. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400268 |
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| Albertoni,Guilherme Ambrozio; Arnoni,Carine Prisco; Araujo,Patricia Regina Barboza; Andrade,Sheila Siqueira; Carvalho,Fabrício Oliveira; Girão,Manoel João Batista Castello; Schor,Nestor; Barreto,José Augusto. |
| Nucleic acid amplification testing (NAT) was recently recommended by Brazilian legislation and has been implemented at some blood banks in the city of São Paulo, Brazil, in an attempt to reduce blood-born transmission of human immunodeficiency virus (HIV) and hepatitis C virus. OBJECTIVE: Manual magnetic particle-based extraction methods for HIV and HCV viral nucleic acids were evaluated in combination with detection by reverse transcriptase - polymerase chain reaction (RT-PCR) one-step. METHODS: Blood donor samples were collected from January 2010 to September 2010, and minipools of them were submitted to testing. ELISA was used for the analysis of anti-HCV/HIV antibodies. Detection and amplification of viral RNA was performed using real-time PCR.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HCV; HIV; Infection; Reverse transcriptase polymerase chain reaction; Blood banks. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600008 |
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| Cahn,P; Leite,O; Rosales,A; Cabello,R; Alvarez,CA; Seas,C; Carcamo,C; Cure-Bolt,N; L'Italien,Gp; Mantilla,P; Deibis,L; Zala,C; Suffert,T. |
| OBJECTIVE: Determine the prevalence of metabolic abnormalities (MA) and estimate the 10-year risk for cardiovascular disease (CVD) among Latin American HIV-infected patients receiving highly active anti-retroviral therapy (HAART). METHODS: A cohort study to evaluate MA and treatment practices to reduce CVD has been conducted in seven Latin American countries. Adult HIV-infected patients with at least one month of HAART were enrolled. Baseline data are presented in this analysis. RESULTS: A total of 4,010 patients were enrolled. Mean age (SD) was 41.9 (10) years; median duration of HAART was 35 (IQR: 10-51) months, 44% received protease inhibitors. The prevalence of dyslipidemia and metabolic syndrome was 80.2% and 20.2%, respectively. The overall 10-year... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HAART; HIV; Metabolic parameters; Cardiovascular risk factors; Metabolic syndrome; Dyslipidemia. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200008 |
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| Akl,Lívia D.; Valadares,Ana L.R.; Moraes,Monica Jacques de; Pinto-Neto,Aarão M.; Lagrutta,Bianca; Costa-Paiva,Lúcia. |
| ABSTRACT Objectives: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. Methods: Cross-sectional study including 273 HIV-infected climacteric women of 40-60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters. Results: Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metabolic syndrome; Menopause; HIV; Protease inhibitors. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300263 |
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| Alvarez,C; Salazar,R; Galindez,J; Rangel,F; Castañeda,ML; Lopardo,G; Cuhna,CA; Roldan,Y; Sussman,O; Gutierrez,G; Cure-Bolt,N; Seas,C; Carcamo,C; Castrillo,M. |
| OBJECTIVE: To evaluate the prevalence of and the associated factors for metabolic syndrome (MS) among Latin American HIV-infected patients receiving antiretroviral therapy (ART) using baseline data from the RAPID II study. METHODS: A longitudinal study to evaluate the metabolic profile, cardiovascular disease (CVD) risk and associated treatment practices to reduce this risk has been conducted in seven Latin American countries (the RAPID II study). Adult HIV patients with at least six months of RT were enrolled. MS was defined following ATP-III criteria. Demographic and anthropometric data, serum biochemical and clinical parameters were compared in patients with and without MS using bivariate and multivariate analysis. RESULTS: A total of 4,010 patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metabolic syndrome (MS); HIV; ART; Latin America. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300010 |
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| da Silva,D.R.; Gluz,I.C.; Kurz,J.; Thomé,G.G.; Zancan,R.; Bringhenti,R.N.; Schaefer,P.G.; dos Santos,M.; Barros,E.J.G.; Veronese,F.V.. |
| HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Renal disease; Proteinuria; Collapsing focal segmental glomerulosclerosis; CD4 cell count; Chronic kidney disease. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400709 |
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| Hofer,Cristina B.; Oliveira,Ricardo Hugo; Machado,Elizabeth S.; Pala,Alessandra; Evangelista,Lúcia; Fernandes,Iraina; Abreu,Thalita F.. |
| There are only scarce data on HIV progression in vertically infected children in developing countries. The aim of this study is to describe factors from neonatal period associated with long term non-progression (LTNP), in a Brazilian cohort. A cohort study, with data systematically collected from the "Peixe" Cohort (cohort study of children conducted at the main HIV Pediatric Center in Rio de Janeiro, from 1996 to 2005). The study included children who were vertically infected and started follow up at 5 years of age or younger. LTNP, defined as not reaching category C or severe immunosuppression before 5 years of age. Neonatal and demographic factors were studied. Variables with p-value<0.15 were included in a logistic regression model. 213 patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Antiretroviral therapy; Long term non-progressors; Children; Brazil. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400007 |
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| Pinto Neto,Lauro Ferreira da Silva; Bassetti,Bil Randerson; Fraga,Igor Hernandes Valvassoura; Oliveira Santos,Carolina Rocio; Ximenes,Paula Daher; Miranda,Angélica Espinosa. |
| Abstract In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine levels and estimated clearance at 0, 6, 12, 24 and 36 months, adjusting for the co-variables sex, skin color, age >50 years, arterial hypertension, diabetes and the use of the ritonavir-boosted protease inhibitors (PI/r) lopinavir/r or atazanavir/r. The software package STATISTICA 10® was used for statistical analysis. The patients’ mean age was 43.2 ± 10.7 years. Systemic arterial hypertension (SAH) and diabetes were found in 20.4% and 8.7% of the patients, respectively. Overall, 96.7% were on... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tenofovir; Nephrotoxicity; Impaired renal function; HIV. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100014 |
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| Corti,Marcelo; Carolis,Luis De; Solari,Rubén; Villafañe,María F; Schtirbu,Ricardo; Lewi,Daniel; Narbaitz,Marina. |
| Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cell lymphomas presenting clinically in the skin without evidence of extra-cutaneous involvement has been accepted as primary CBCL. Here, we are presenting 5 patients with cutaneous involvement in the setting of HIV/AIDS disease. Two of them were primary cutaneous non-Hodgkin lymphomas. All were CBCL; 3 were immunoblastic, 1 was plasmablastic, and the other was a... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: AIDS; HIV; Cutaneous lymphoma. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100016 |
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| Galhardo,M.C.G.; Alvarenga,F.F.; Schueler,G.; Perez,M.; Morgado,M.G.; Ferreira,H.; Azevedo,L.M.S.; Sampaio,E.P.; Sarno,E.N.. |
| Dysregulation of the skin immune system (SIS) could explain the high prevalence of skin disorders in HIV+ individuals. The present study was carried out to determine whether alterations in the cell population of SIS and epidermal immunoactivation occur in the normal skin of HIV+ individuals. Forty-five biopsies were taken from the normal upper arm skin of 45 HIV+ patients and of 15 healthy controls. HIV+ individuals were divided into three categories according to their CD4 cell blood count (<200, 200-499 and ³500/µl). Hematoxylin-eosin was used to stain tissue sections for morphological analysis and immunohistochemistry was used for the evaluation of the frequency of macrophages, Langerhans cells, and CD lymphocyte subsets. In addition, semiquantitative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Skin immune system; CD8 T cells; CD4-CD8 ratio; Langerhans cells. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500017 |
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| Lima,Ana Lúcia Lei Munhoz; Zumiotti,Arnaldo Valdir; Camanho,Gilberto Luis; Benegas,Eduardo; Santos,Alexandre Leme Godoy dos; D'Elia,Caio Oliveira; Oliveira,Priscila Rosalba Domingos. |
| With the significant increase in life expectancy for HIV-infected patients in the era of high potency antiretroviral therapy, major metabolic changes have been observed due to the prolonged period of the viral infection and the treatment itself. Osteoarticular changes resulting from these processes are mainly reported in long term HIV-infected patients receiving high potency antiretroviral therapy and include osteopenia/osteoporosis, osteonecrosis, carpal tunnel syndrome and adhesive capsulitis of the shoulder. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Acquired immunodeficiency syndrome; Osteoarticular; Antiretroviral agents. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400012 |
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| SANTOS,PAULO C.C. DOS; LOPES,HELDER F.S.; ALCALDE,ROSANA; GONSALEZ,CLÁUDIO R.; ABE,JAIR M.; LOPEZ,LUIS F.. |
| ABSTRACT The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug leads to fixation of mutations capable of imparting varying degrees of resistance. The presence of these mutations is one of the most important factors in the failure of therapeutic response to medications. Thus, it is of critical to understand the resistance patterns and mechanisms associated with them, allowing the choice of an appropriate therapeutic scheme, which considers the frequency, and other characteristics of mutations. Utilizing Paraconsistents Artificial Neural Networks, seated in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artificial Neural Networks; HIV; Genotyping; Paraconsistent logic; Paraconsistents Artificial Neural Networks; Pattern recognition. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100323 |
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| Dehner,Luis Filipe; Spitz,Mariana; Pereira,João Santos. |
| Abstract Introduction Advances in the treatment of HIV infection in the last decades have increased life expectancy of these patients and raise the question of what kind of effect chronic infection and its treatment might exert on the behavior of age-related conditions such as neurodegenerative diseases. Patient data We performed a retrospective analysis of patients’ records to assess the frequency of the association between HIV infection and parkinsonian symptoms in our hospital population. Among 249 records we identified four individuals with reported parkinsonian symptoms initiated after HIV diagnosis. Three of them had no other identifiable cause of secondary parkinsonism. All had symptom onset before the age of 60. Based on this study sample one... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Parkinsonism; HIV; Antiretroviral therapy. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500499 |
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| Romeu,Geysa Aguiar; Paiva,Larissa Varela de; Fé,Mariana Mota Moura. |
| The purpose of this present study was to know the pharmacoepidemiological profile of pregnant women carrying HIV, the prevention actions against vertical transmission, and evaluate the service respecting the patients' level of satisfaction. It was developed a quali-quantitative longitudinal study, with the sample being composed by pregnant women carrying HIV attended at the Pharmaceutical Care Service of a public hospital of Fortaleza - state of Ceará, during the period between January and September, 2007. The data were collected by means of follow-up cards, patients' medical history and, finally, interviews to verify the users' level of satisfaction related to the service. Twenty seven pregnant and parturient women have participated in the study. The mean... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmacoepidemiology; Pharmaceutical Care; HIV; Pregnant women/pharmacoepidemiological profile. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300026 |
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| Novakovic,Marko; Turkulov,Vesna; Maric,Daniela; Kozic,Dusko; Rajkovic,Uros; Bjelan,Mladen; Lucic,Milos; Brkic,Snezana. |
| ABSTRACTBACKGROUND: Despite potent antiretroviral therapy, HIV still causes brain damage. Better penetration into the CNS and efficient elimination of monocyte/macrophages reservoirs are two main characteristics of an antiretroviral drug that could prevent brain damage. The aim of our study was to assess efficacy of three antiretroviral drug scores to predict brain atrophy in HIV-infected patients.METHODS:A cross sectional study consisting of 56 HIV-infected patients with controlled viremia, who had no clinically evident neurocognitive impairment. All patients had MRI of the head. A typical T2 transversal slice was analyzed and ventricles-brain ratio (VBr) as an overall brain atrophy index was calculated. Three antiretroviral drug scores were used and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CPE; Monocyte efficacy score; Brain atrophy; HAART; HIV. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500503 |
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| Registros recuperados: 191 | |
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